10.6084/m9.figshare.5644579.v1
Esra Nur Ademoglu
Esra Nur
Ademoglu
Suheyla Gorar
Suheyla
Gorar
Muge Keskin
Muge
Keskin
Ayse Carlioglu
Ayse
Carlioglu
Rifki Ucler
Rifki
Ucler
Husamettin Erdamar
Husamettin
Erdamar
Cavit Culha
Cavit
Culha
Yalcin Aral
Yalcin
Aral
Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes
SciELO journals
2017
Gestational diabetes
nesfatin-1
insulin resistance
2017-11-29 11:57:28
Dataset
https://scielo.figshare.com/articles/dataset/Serum_nesfatin-1_levels_are_decreased_in_pregnant_women_newly_diagnosed_with_gestational_diabetes/5644579
<div><p>ABSTRACT Objective To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.</p></div>