Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats Maryam Malek Alireza Sarkaki Saleh Zahedi-Asl Yaghoob Farbood Ziba Rajaei 10.6084/m9.figshare.5644519.v1 https://scielo.figshare.com/articles/dataset/Effect_of_intra-hippocampal_injection_of_human_recombinant_growth_hormone_on_synaptic_plasticity_in_the_nucleus_basalis_magnocellularis-lesioned_aged_rats/5644519 <div><p>ABSTRACT In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six groups (seven in each) of sham-operated healthy rats (Cont); NBM-lesioned rats (L); NBM-lesioned rats and intrahippocampal injection of growth hormone vehicle (L + Veh); NBM-lesioned and intrahippocampal injection of growth hormone (10, 20 and 40 µg.2 µl-1) (L + GH). In vivo electrophysiological recording techniques were used to characterize maintenance of long-term potentiation at distinct times (1, 2, 3, 24 and 48 hours) after high-frequency stimulation. The population spike was enhanced significantly for about 48 hours following tetanic stimulation in rats treated with a dose-dependent growth hormone compared to the vehicle group (p < 0.05), possibly through neuronal plasticity and neurogenesis in affected areas.</p></div> 2017-11-29 11:51:52 growth hormone hippocampus basal nucleus of Meynert long-term potentiation Alzheimer disease cognition disorders