Alves, Endrigo Gabellini Leonel Serakides, Rogéria Rosado, Isabel Rodrigues Paez, Omar Leonardo Aristizabal Varon, Jéssica Alejandra Castro Machado, Felipe Nemer Fukushima, Fabíola Bono Góes, Alfredo Miranda Rezende, Cleuza Maria de Faria Osteoprogenitor cells can enhance early bone formation in critical bone defects in dogs <div><p>ABSTRACT: The aim of this study was to evaluate the effect of osteoprogenitor cells derived from mesenchymal stem cells from adipose tissue (OC-AD-MSCs), and differentiated into osteoblasts, in the treatment of critical bone defects in dogs. Adipose tissue derived mesenchymal stem cells (AD-MSCs) were subjected to osteogenic differentiation for 21 days and used in the treatment of bone defects in dogs radius. Either three experimental groups were bone defects treated with OC-AD-MSCs (OC), defects filled with autogenous bone (Control- C +), or empty defects (Control- C -). Bone regeneration was assessed by radiology, densitometry, and histomorphometry. The area of new bone formation was higher in the OC group compared to the control group (C-) on postoperative day 15. Defects treated with OC-AD-MSCs showed greater neovascularization than the other two groups at 90 days. We concluded that treatment with OC-AD-MSCs increased the area of new bone formation 15 days after surgery; however, it didn’t complete the bone union in critical bone defects in the radius of dogs at 90 days.</p></div> bone regeneration;orthopedics;cellular therapy;fracture non-union 2017-11-29
    https://scielo.figshare.com/articles/dataset/Osteoprogenitor_cells_can_enhance_early_bone_formation_in_critical_bone_defects_in_dogs/5634964
10.6084/m9.figshare.5634964