10.6084/m9.figshare.5634928
José Daniel Vieira de Castro
José Daniel Vieira de
Castro
Licia Pacheco Pereira
Licia Pacheco
Pereira
Daniel Aguiar Dias
Daniel Aguiar
Dias
Lindenberg Barbosa Aguiar
Lindenberg Barbosa
Aguiar
Joanira Costa Nogueira Maia
Joanira Costa Nogueira
Maia
Jesus Irajacy Fernandes da Costa
Jesus Irajacy Fernandes da
Costa
Eveline Campos Monteiro de Castro
Eveline Campos Monteiro de
Castro
Francisco Edson de Lucena Feitosa
Francisco Edson de Lucena
Feitosa
Francisco Herlânio Costa Carvalho
Francisco Herlânio Costa
Carvalho
Presumed Zika virus-related congenital brain malformations: the spectrum of CT and MRI findings in fetuses and newborns
SciELO journals
2017
Zika virus
microcephaly
tomography
X-ray computed
magnetic resonance imaging
2017-11-29 11:29:53
Dataset
https://scielo.figshare.com/articles/dataset/Presumed_Zika_virus-related_congenital_brain_malformations_the_spectrum_of_CT_and_MRI_findings_in_fetuses_and_newborns/5634928
<div><p>ABSTRACT The new epidemic of Zika virus infection raises grave concerns, especially with the increasingly-recognized link between emerging cases of microcephaly and this infectious disease. Besides small cranial dimensions, there are striking morphologic anomalies in the fetal brain. Key anomalies include cortical developmental malformations and a peculiar distribution of pathologic calcifications. These potentially indicate a new pattern of congenital central nervous system infection. Methods: Eight women underwent fetal MRI. Four infants also underwent postnatal CT. Five of the women underwent amniocentesis. Results: All neonates were born with microcephaly. On fetal MRI, ventriculomegaly, marked reduction of white matter thickness, severe sylvian fissure simplification, abnormal sulcation, and diffuse volumetric loss of cerebellar hemispheres were consistently seen. On postnatal CT, diffuse subcortical and basal ganglia calcifications were observed. The Zika virus was detected in two amniocenteses by polymerase chain reaction assays. Conclusion: We hope to assist the medical community in recognizing the spectrum of encephalic changes related to congenital Zika virus infection.</p></div>