Gasparotto, Aline Simas Borges, Diego Olschowsky Zandoná, Marília Remuzzi Ramos, Mauricio Jacques Meihnardt, Nelson Guardiola Mattevi, Vanessa S. Adiponectin promoter polymorphisms are predictors of lipid profile improvement after bariatric surgery <div><p>Abstract Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes. Approximately 32 months post-surgery, a mean reduction of 35% in BMI and an important improvement in metabolic profiles were observed. In addition, for the ADIPOQ -11377 polymorphism, a higher decrease in lipid profile was associated to the C/C genotype. Moreover, individuals bearing the A-C haplotype for the two ADIPOQ SNPs were more prone to show a reduction in low-density lipoprotein levels after bariatric surgery (-43.0% A-C carriers vs. -18.1% G-G carriers, p = 0.019). We did not find any association of leptin and resistin SNPs with the clinical parameters analyzed. In summary, our results indicate that the A-C haplotype is a predictor of better lipid profile post-surgery and the studied SNPs in ADIPOQ gene are associated to changes in metabolic variables in obese individuals.</p></div> Adiponectin;polymorphism;obesity;lipid profile;bariatric surgery 2017-11-29
    https://scielo.figshare.com/articles/dataset/Adiponectin_promoter_polymorphisms_are_predictors_of_lipid_profile_improvement_after_bariatric_surgery/5634364
10.6084/m9.figshare.5634364