Hausmann, George von Mering, Christian Basler, Konrad Ptc and Disp, two key proteins the Hh pathway, in their evolutionary context. <p>(A) A phylogenetic tree of proteins related to Patched, limited to proteins that are full-length (i.e., those that contain all 12 transmembrane segments), is shown. The tree is color-coded according to the taxonomy of the organisms in which the respective proteins are found. Note one particular family of deeply branching bacterial Ptc homologs, the HpnN family, which encodes a transporter that is predicted to be associated with hopanoid biosynthesis. (B) A typical hopanoid is shown, next to cholesterol, a typical sterol. (C) Sequence alignment of selected HpnN family members with the most common reciprocal-best-match, the Disp family, is shown. Only six sequences are shown (three bacterial and three eukaryotic proteins); the alignment is restricted to transmembrane segments 2 to 6, which form the so-called SSD. (D) and (E) Evidence is shown for a functional association between HpnN-family transporters and HpnF; the latter being the enzyme that catalyzes the first step of hopanoid biosynthesis. Both genes tend to be either present or absent together in a given genome in proteobacteria and occasionally occur in direct chromosomal proximity.</p> proteins;hh;evolutionary 2009-06-30
    https://plos.figshare.com/articles/figure/_Ptc_and_Disp_two_key_proteins_the_Hh_pathway_in_their_evolutionary_context_/563306
10.1371/journal.pbio.1000146.g002