10.6084/m9.figshare.5632615 Kazuo Iwasa Kazuo Iwasa Hiroaki Yoshikawa Hiroaki Yoshikawa Tsuyoshi Hamaguchi Tsuyoshi Hamaguchi Kenji Sakai Kenji Sakai Moeko Shinohara-Noguchi Moeko Shinohara-Noguchi Miharu Samuraki Miharu Samuraki Kazuya Takahashi Kazuya Takahashi Daisuke Yanase Daisuke Yanase Kenjiro Ono Kenjiro Ono Chiho Ishida Chiho Ishida Mitsuhiro Yoshita Mitsuhiro Yoshita Hiroyuki Nakamura Hiroyuki Nakamura Masahito Yamada Masahito Yamada Time-series analysis: variation of anti-acetylcholine receptor antibody titer in myasthenia gravis is related to incidence of <i>Mycoplasma pneumoniae</i> and influenza virus infections Taylor & Francis Group 2017 Myasthenia gravis anti-acetylcholine receptor antibody Mycoplasma pneumoniae influenza virus immune response 2017-11-25 07:31:22 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Time-series_analysis_variation_of_anti-acetylcholine_receptor_antibody_titer_in_myasthenia_gravis_is_related_to_incidence_of_i_Mycoplasma_pneumoniae_i_and_influenza_virus_infections/5632615 <p>The exacerbating factors of myasthenia gravis (MG) are unknown. However, it has been speculated that infections may play a role in disease progression.</p> <p>We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0–1) in 58 MG patients between 2006 and 2012. We determined the relationship between Adj-AChR-Ab titer and infection incidence.</p> <p>A cross-correlation function (CCF) analysis of Adj-AChR-Ab titer and incidence of <i>Mycoplasma pneumoniae</i> (<i>M. pneumoniae</i>) (<i>r</i> = 0.449, <i>P</i> < 0.0001) and influenza virus (<i>r</i> = 0.411, <i>P</i> < 0.001) infections indicated significant correlations. MG with thymoma was highly correlated with <i>M. pneumoniae</i> infection (<i>r</i> = 0.798, <i>P</i> < 0.0001). The relative risk for Adj-AChR-Ab titer was 1.407 for <i>M. pneumoniae</i> (95% CI, 1.193–1.661 for an increase in one infected patient per monitoring point) and 1.158 for influenza (95% CI, 1.071–1.253 for 100 infected patients).</p> <p>Variation of Adj-AChR-Ab titer is significantly influenced by the presence of <i>M. pneumoniae</i> and influenza virus infections.</p>