10.6084/m9.figshare.5632615
Kazuo Iwasa
Kazuo
Iwasa
Hiroaki Yoshikawa
Hiroaki
Yoshikawa
Tsuyoshi Hamaguchi
Tsuyoshi
Hamaguchi
Kenji Sakai
Kenji
Sakai
Moeko Shinohara-Noguchi
Moeko
Shinohara-Noguchi
Miharu Samuraki
Miharu
Samuraki
Kazuya Takahashi
Kazuya
Takahashi
Daisuke Yanase
Daisuke
Yanase
Kenjiro Ono
Kenjiro
Ono
Chiho Ishida
Chiho
Ishida
Mitsuhiro Yoshita
Mitsuhiro
Yoshita
Hiroyuki Nakamura
Hiroyuki
Nakamura
Masahito Yamada
Masahito
Yamada
Time-series analysis: variation of anti-acetylcholine receptor antibody titer in myasthenia gravis is related to incidence of <i>Mycoplasma pneumoniae</i> and influenza virus infections
Taylor & Francis Group
2017
Myasthenia gravis
anti-acetylcholine receptor antibody
Mycoplasma pneumoniae
influenza virus
immune response
2017-11-25 07:31:22
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Time-series_analysis_variation_of_anti-acetylcholine_receptor_antibody_titer_in_myasthenia_gravis_is_related_to_incidence_of_i_Mycoplasma_pneumoniae_i_and_influenza_virus_infections/5632615
<p>The exacerbating factors of myasthenia gravis (MG) are unknown. However, it has been speculated that infections may play a role in disease progression.</p> <p>We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0–1) in 58 MG patients between 2006 and 2012. We determined the relationship between Adj-AChR-Ab titer and infection incidence.</p> <p>A cross-correlation function (CCF) analysis of Adj-AChR-Ab titer and incidence of <i>Mycoplasma pneumoniae</i> (<i>M. pneumoniae</i>) (<i>r</i> = 0.449, <i>P</i> < 0.0001) and influenza virus (<i>r</i> = 0.411, <i>P</i> < 0.001) infections indicated significant correlations. MG with thymoma was highly correlated with <i>M. pneumoniae</i> infection (<i>r</i> = 0.798, <i>P</i> < 0.0001). The relative risk for Adj-AChR-Ab titer was 1.407 for <i>M. pneumoniae</i> (95% CI, 1.193–1.661 for an increase in one infected patient per monitoring point) and 1.158 for influenza (95% CI, 1.071–1.253 for 100 infected patients).</p> <p>Variation of Adj-AChR-Ab titer is significantly influenced by the presence of <i>M. pneumoniae</i> and influenza virus infections.</p>