The cardiovascular benefits of indiscriminate supplementation of omega-3 fatty acids; meta-analysis and decision-making approach M. Leshno U. Goldbourt I. Pinchuk D. Lichtenberg 10.6084/m9.figshare.5631928.v1 https://tandf.figshare.com/articles/journal_contribution/The_cardiovascular_benefits_of_indiscriminate_supplementation_of_omega-3_fatty_acids_meta-analysis_and_decision-making_approach/5631928 <p><b>Aim:</b> The meta-analysis was conducted to estimate of the cardiovascular benefits of indiscriminate supplementation of omega-3 capsules. The results, expressed in terms of quality adjusted life years (QALY) intuitively understood by the general public, can be the basis for the (personal) decision on whether to take omega-3 supplements.</p> <p><b>Methods:</b> The results of meta-analysis of eight double-blind, placebo-controlled clinical trials are expressed in terms of QALY, using the Markov model and Monte Carlo simulations.</p> <p><b>Results:</b> Omega-3 supplementation results in a 8% decrease of the risk of cardiac death, unless the patients are treated by statins. Results indicate that omega-3 supplementation may prolong QALY by about a month. Old people gain less, whereas DM-2 patients and people with history of CV events gain more.</p> <p><b>Discussion:</b> Our analysis yielded an algorithm for estimating benefit from omega-3 supplementation, based on the age and the individual risk of CV events of the patient.</p> 2017-11-24 12:18:07 Omega-3 supplementation cardiovascular morbidity and mortality statins