10.6084/m9.figshare.5629993.v1 Artem Kondratskyi Artem Kondratskyi Kateryna Kondratska Kateryna Kondratska Roman Skryma Roman Skryma Daniel J. Klionsky Daniel J. Klionsky Natalia Prevarskaya Natalia Prevarskaya Ion channels in the regulation of autophagy Taylor & Francis Group 2017 autophagy calcium chloride ion channels potassium sodium 2017-11-23 11:19:12 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Ion_channels_in_the_regulation_of_autophagy/5629993 <p>Autophagy is a cellular process in which the cell degrades and recycles its own constituents. Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is associated with various diseases. Hence, a thorough understanding of autophagy regulatory mechanisms is crucially important for the elaboration of efficient treatments for different diseases. Recently, ion channels, mediating ion fluxes across cellular membranes, have emerged as important regulators of both basal and induced autophagy. However, the mechanisms by which specific ion channels regulate autophagy are still poorly understood, thus underscoring the need for further research in this field. Here we discuss the involvement of major types of ion channels in autophagy regulation.</p>