10.6084/m9.figshare.5629993.v1
Artem Kondratskyi
Artem
Kondratskyi
Kateryna Kondratska
Kateryna
Kondratska
Roman Skryma
Roman
Skryma
Daniel J. Klionsky
Daniel
J. Klionsky
Natalia Prevarskaya
Natalia
Prevarskaya
Ion channels in the regulation of autophagy
Taylor & Francis Group
2017
autophagy
calcium
chloride
ion channels
potassium
sodium
2017-11-23 11:19:12
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Ion_channels_in_the_regulation_of_autophagy/5629993
<p>Autophagy is a cellular process in which the cell degrades and recycles its own constituents. Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is associated with various diseases. Hence, a thorough understanding of autophagy regulatory mechanisms is crucially important for the elaboration of efficient treatments for different diseases. Recently, ion channels, mediating ion fluxes across cellular membranes, have emerged as important regulators of both basal and induced autophagy. However, the mechanisms by which specific ion channels regulate autophagy are still poorly understood, thus underscoring the need for further research in this field. Here we discuss the involvement of major types of ion channels in autophagy regulation.</p>