%0 Figure %A Kodihalli, Shantha %A Emanuel, Andrew %A Takla, Teresa %A Hua, Yi %A Hobbs, Charles %A LeClaire, Ross %A O’Donnell, Denise C. %D 2017 %T Kaplan-Meier survival curves for BoNT/A intoxicated monkeys treated with BAT. %U https://plos.figshare.com/articles/figure/Kaplan-Meier_survival_curves_for_BoNT_A_intoxicated_monkeys_treated_with_BAT_/5626465 %R 10.1371/journal.pone.0186892.g002 %2 https://ndownloader.figshare.com/files/9800818 %K dose %K Botulism Antitoxin Heptavalent %K survival %K equine botulism antitoxin %K botulinum neurotoxin serotype %K 4 hours post-exposure %K placebo %K PEP %K Rhesus macaques Background %K 1 x %K LD %X

Groups of monkeys (n = 30/group) were intoxicated with 1.7x LD50/kg dose of BoNT/A and monitored hourly for the onset of clinical signs. Monkeys were individually administered with either BAT at 1x scaled human dose or placebo intravenously after the onset of clinical signs indicative of botulism (Study 2) and monitored for survival to 21 days post-toxin exposure.

%I PLOS ONE