Two new clerodane-type diterpenoids from Bornean liverwort <i>Gottschelia schizopleura</i> and their cytotoxic activity Shean-Yeaw Ng Takashi Kamada Monica Suleiman Charles Santhanaraju Vairappan 10.6084/m9.figshare.5619628 https://tandf.figshare.com/articles/journal_contribution/Two_new_clerodane-type_diterpenoids_from_Bornean_liverwort_i_Gottschelia_schizopleura_i_and_their_cytotoxic_activity/5619628 <p>The Bornean liverwort <i>Gottschelia schizopleura</i> was investigated phytochemically for the first time. Two new and four previously known clerodane-type diterpenoids were isolated from the MeOH extract of <i>G. schizopleura</i> through a series of chromatographic techniques. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS and IR). All the isolated compounds <b>1</b>–<b>6</b> were tested against human promyelocytic leukaemia (HL-60), human colon adenocarcinoma (HT-29) and Mus musculus skin melanoma (B16-F10). Compound <b>1</b> and <b>2</b> showed active inhibition against HL-60 and B16-F10 cells.</p> 2017-11-21 03:12:33 Clerodane diterpenoids Gottschelia schizopleura Jungermanniaceae liverwort Borneo cytotoxic activity