10.6084/m9.figshare.5607337.v1 Nguyen Thi Huong Nguyen Thi Huong Ninh Thi Ngoc Ninh Thi Ngoc Nguyen Van Thanh Nguyen Van Thanh Nguyen Hai Dang Nguyen Hai Dang Nguyen Xuan Cuong Nguyen Xuan Cuong Nguyen Hoai Nam Nguyen Hoai Nam Do Cong Thung Do Cong Thung Ho Van The Ho Van The Vo Sy Tuan Vo Sy Tuan Phan Van Kiem Phan Van Kiem Chau Van Minh Chau Van Minh Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral <i>Sinularia erecta</i> Taylor & Francis Group 2017 Sinularia erecta sesquiterpenoid eudesmane aromadendrane cytotoxicity 2017-11-16 13:38:19 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Eudesmane_and_aromadendrane_sesquiterpenoids_from_the_Vietnamese_soft_coral_i_Sinularia_erecta_i_/5607337 <p>Using various chromatographic separations, eight sesquiterpenoids (<b>1</b>–<b>8</b>), including one new compound 3<i>β</i>,5<i>α</i>-dihydroxyeudesma-4(15),11-diene (<b>1</b>), were isolated from the MeOH extract of the Vietnamese soft coral <i>Sinularia erecta</i>. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound <b>1</b> exhibited selective cytotoxicity against the A549 cell line with IC<sub>50</sub> of 14.79 ± 0.91 μM.</p>