10.6084/m9.figshare.5607337.v1
Nguyen Thi Huong
Nguyen Thi
Huong
Ninh Thi Ngoc
Ninh Thi
Ngoc
Nguyen Van Thanh
Nguyen
Van Thanh
Nguyen Hai Dang
Nguyen
Hai Dang
Nguyen Xuan Cuong
Nguyen Xuan
Cuong
Nguyen Hoai Nam
Nguyen Hoai
Nam
Do Cong Thung
Do
Cong Thung
Ho Van The
Ho
Van The
Vo Sy Tuan
Vo Sy
Tuan
Phan Van Kiem
Phan Van
Kiem
Chau Van Minh
Chau Van
Minh
Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral <i>Sinularia erecta</i>
Taylor & Francis Group
2017
Sinularia erecta
sesquiterpenoid
eudesmane
aromadendrane
cytotoxicity
2017-11-16 13:38:19
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Eudesmane_and_aromadendrane_sesquiterpenoids_from_the_Vietnamese_soft_coral_i_Sinularia_erecta_i_/5607337
<p>Using various chromatographic separations, eight sesquiterpenoids (<b>1</b>–<b>8</b>), including one new compound 3<i>β</i>,5<i>α</i>-dihydroxyeudesma-4(15),11-diene (<b>1</b>), were isolated from the MeOH extract of the Vietnamese soft coral <i>Sinularia erecta</i>. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound <b>1</b> exhibited selective cytotoxicity against the A549 cell line with IC<sub>50</sub> of 14.79 ± 0.91 μM.</p>