10.6084/m9.figshare.5602777.v1
Rossella Russo
Rossella
Russo
Laura Pucci
Laura
Pucci
Lucia Giorgetti
Lucia
Giorgetti
Július Árvay
Július
Árvay
Francesco Vizzarri
Francesco
Vizzarri
Vincenzo Longo
Vincenzo
Longo
Luisa Pozzo
Luisa
Pozzo
Polyphenolic characterisation of plant mixture (Lisosan® Reduction) and its hypocholesterolaemic effect in high fat diet-fed mice
Taylor & Francis Group
2017
Plant mixture
polyphenolic profile
hypercholesterolaemia
hepatic mRNA
mice
2017-11-15 12:19:17
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Polyphenolic_characterisation_of_plant_mixture_Lisosan_Reduction_and_its_hypocholesterolaemic_effect_in_high_fat_diet-fed_mice/5602777
<p>Lisosan® Reduction is a plant mixture produced from powder of fermented <i>Triticum aestivum</i> (Lisosan® G)<i>, Desmodium adscendens, Malus domestica, Picrorhiza kurroa</i> and <i>Hordeum vulgare.</i> The aim of this study was to characterise the phenolic profile of Lisosan® Reduction and to evaluate the effects of aqueous extract on mice fed a high fat diet (HFD). Syringic acid, trans sinapic acid and neochlorogenic acid were identified by HPLC-DAD to be the dominant polyphenols of Lisosan® Reduction, followed by vitexin, trans p-coumeric acid and trans ferulic acid. Mice treated with aqueous extract of Lisosan® Reduction (60 mg/kg b.w.) showed a significant decrease of serum cholesterol, glucose and triglycerides level and a significant increase of CYP7A1 gene expression, compared to HFD group.</p>