10.6084/m9.figshare.5594278.v1
Jing-Tang Liu
Jing-Tang
Liu
Wei Wu
Wei
Wu
Min-Jia Cao
Min-Jia
Cao
Fan Yang
Fan
Yang
Hou-Wen Lin
Hou-Wen
Lin
Trienic α-pyrone and ochratoxin derivatives from a sponge-derived fungus <i>Aspergillus ochraceopetaliformis</i>
Taylor & Francis Group
2017
Sponge-derived fungus
Aspergillus ochraceopetaliformis
trienic α-pyrone
ochratoxin
anti-inflammatory
2017-11-13 13:06:26
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Trienic_-pyrone_and_ochratoxin_derivatives_from_a_sponge-derived_fungus_i_Aspergillus_ochraceopetaliformis_i_/5594278
<p>A new trienic α-pyrone derivative asteltoxin G (<b>1</b>) bearing a tetrahydrofuran ring and a new ochratoxin derivative named ochratoxin A<sub>1</sub> (<b>5</b>), along with seven known compounds, were isolated from a sponge-derived fungus <i>Aspergillus ochraceopetaliformis</i>. The compounds (<b>1</b>–<b>9</b>) were evaluated on the basis of spectroscopic analyses and comparison with those of the reported data. The new compound ochratoxin A<sub>1</sub> (<b>5</b>) exhibited anti-inflammatory activity against IL-6 and TNF-α expression of the LPS-induced THP-1 cells with inhibitory rates of 74.4 and 67.7% at concentration of 10 μM, respectively.</p>