%0 Journal Article %A Simas, Daniel Luiz Reis %A Mérida-Reyes, Max Samuel %A Muñoz-Wug, Manuel Alejandro %A Cordeiro, Millena Santos %A Giorno, Thais Biondino Sardella %A Taracena, Edwin Adolfo %A Oliva-Hernández, Bessie Evelyn %A Martínez-Arévalo, José Vicente %A Fernandes, Patricia Dias %A Pérez-Sabino, Juan Francisco %A da Silva, Antonio Jorge Ribeiro %D 2017 %T Chemical composition and evaluation of antinociceptive activity of the essential oil of Stevia serrata Cav. from Guatemala %U https://tandf.figshare.com/articles/journal_contribution/Chemical_composition_and_evaluation_of_antinociceptive_activity_of_the_essential_oil_of_i_Stevia_serrata_i_Cav_from_Guatemala/5594179 %R 10.6084/m9.figshare.5594179.v1 %2 https://ndownloader.figshare.com/files/9731695 %K Antinocicepive activity %K Stevia serrata Cav. %K essential oil %K sesquiterpenes %K chamazulene %X

The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil was obtained by hydrodistillation of the dried aerial parts of the plant. The essential oil analysed by GC-FID and GC-MS showed a high content of sesquiterpenoids, with chamazulene (60.1%) as the major component and 91.5% of the essential oil composition was identified. To evaluate antinociceptive activity in mice, the essential oil of S. serrata Cav. was administered as gavage, using three different doses. In the formalin test, the animals were pre-treated with oral doses of the essential oil before the administration of formalin. Oral administration of S. serrata Cav. essential oil produced a marked antinociceptive activity. Therefore, the plant could be domesticated as a source of essential oil rich in chamazulene for developing medicinal products.

%I Taylor & Francis