10.6084/m9.figshare.5584387.v1 Paula Araújo Monteiro Paula Araújo Monteiro Ícaro Augusto Maccari Zelioli Ícaro Augusto Maccari Zelioli Ilza Maria de Oliveira Sousa Ilza Maria de Oliveira Sousa Ana Lúcia Tasca Gois Ruiz Ana Lúcia Tasca Gois Ruiz Débora Barbosa Vendramini-Costa Débora Barbosa Vendramini-Costa Mary Ann Foglio Mary Ann Foglio João Ernesto de Carvalho João Ernesto de Carvalho Chemical composition and antiproliferative activity of <i>Croton campestris</i> A.St.-Hil. essential oil Taylor & Francis Group 2017 Croton campestris natural products essential oil antiproliferative activity human tumour cell lines gas chromatography and mass spectrometry (GC/MS) concentration necessary to cause 50% growth inhibition (GI50) essential oil from Croton campestris (EOCC) Council for the Genetic Heritage Management (CGEN) 2017-11-09 08:36:10 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Chemical_composition_and_antiproliferative_activity_of_i_Croton_campestris_i_A_St_-Hil_essential_oil/5584387 <p>Herein, the antiproliferative potential of the essential oil obtained from fresh leaves of <i>Croton campestris</i> against human tumour cell lines was investigated for the first time. Furthermore, the essential oil obtained by hydrodistillation had the composition determined by gas chromatography–mass spectrometry (GC/MS). Ten major components were identified that comprised 91.59% of the total content, with 23.8% consisting of <i>(Z)</i>-caryophyllene and 16.08% consisting of <i>γ</i>-elemene as main components. The cytotoxic activity was observed mainly for breast (MCF-7) and colon (HT-29) human tumour cell lines, with GI<sub>50</sub> (50% growth inhibition) concentration of 8.61 and 9.94 μg/mL, respectively. The results of this study showed that the essential oil obtained from <i>Croton campestris</i> A.St.-Hil. represents a potential source for the search of new antitumour agents.</p>