10.6084/m9.figshare.5584387.v1
Paula Araújo Monteiro
Paula Araújo
Monteiro
Ícaro Augusto Maccari Zelioli
Ícaro Augusto Maccari
Zelioli
Ilza Maria de Oliveira Sousa
Ilza Maria
de Oliveira Sousa
Ana Lúcia Tasca Gois Ruiz
Ana Lúcia Tasca Gois
Ruiz
Débora Barbosa Vendramini-Costa
Débora Barbosa
Vendramini-Costa
Mary Ann Foglio
Mary Ann
Foglio
João Ernesto de Carvalho
João
Ernesto de Carvalho
Chemical composition and antiproliferative activity of <i>Croton campestris</i> A.St.-Hil. essential oil
Taylor & Francis Group
2017
Croton campestris
natural products
essential oil
antiproliferative activity
human tumour cell lines
gas chromatography and mass spectrometry (GC/MS)
concentration necessary to cause 50% growth inhibition (GI50)
essential oil from Croton campestris (EOCC)
Council for the Genetic Heritage Management (CGEN)
2017-11-09 08:36:10
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Chemical_composition_and_antiproliferative_activity_of_i_Croton_campestris_i_A_St_-Hil_essential_oil/5584387
<p>Herein, the antiproliferative potential of the essential oil obtained from fresh leaves of <i>Croton campestris</i> against human tumour cell lines was investigated for the first time. Furthermore, the essential oil obtained by hydrodistillation had the composition determined by gas chromatography–mass spectrometry (GC/MS). Ten major components were identified that comprised 91.59% of the total content, with 23.8% consisting of <i>(Z)</i>-caryophyllene and 16.08% consisting of <i>γ</i>-elemene as main components. The cytotoxic activity was observed mainly for breast (MCF-7) and colon (HT-29) human tumour cell lines, with GI<sub>50</sub> (50% growth inhibition) concentration of 8.61 and 9.94 μg/mL, respectively. The results of this study showed that the essential oil obtained from <i>Croton campestris</i> A.St.-Hil. represents a potential source for the search of new antitumour agents.</p>