10.6084/m9.figshare.5584381.v1 Yan-Ming Wang Yan-Ming Wang Jian-Qiang Zhao Jian-Qiang Zhao Jun-Li Yang Jun-Li Yang Pema Tsering Idong Pema Tsering Idong Li-Juan Mei Li-Juan Mei Yan-Duo Tao Yan-Duo Tao Yan-Ping Shi Yan-Ping Shi Antioxidant and <i>α</i>-glucosidase inhibitory ingredients identified from Jerusalem artichoke flowers Taylor & Francis Group 2017 Jerusalem artichoke flowers antioxidant activity α-glucosidase inhibitory effect phenolic compounds 2017-11-09 08:34:02 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Antioxidant_and_i_i_-glucosidase_inhibitory_ingredients_identified_from_Jerusalem_artichoke_flowers/5584381 <p>Jerusalem artichoke (JA, <i>Helianthus tuberosus</i> L.) has been researched extensively due to its wide range of uses, but there are limited studies on its flowers. In this study, we report the first detailed phytochemical study on JA flowers, which yielded 21 compounds. Compound <b>4</b> was identified as a major water-soluble yellow pigment of JA flowers. In addition, the methanol extract of JA flowers and the isolates were evaluated for their antioxidant and <i>α</i>-glucosidase inhibitory activities. Among the tested compounds, compound <b>13</b> showed the strongest ABTS<sup>+</sup> free radical scavenging activity with SC<sub>50</sub> value of 2.30 ± 0.13 μg/mL, and compound <b>6</b> showed most potent <i>α</i>-glucosidase inhibitory activity with inhibition rate of 60.0% ± 10.3% at a concentration of 250 μg/mL. Results showed that methanol extract of JA flowers exhibited antioxidant and <i>α</i>-glucosidase inhibitory activities which could be attributed to its phenolic ingredients including chlorogenic acid derivatives, flavonoids and phenols.</p>