A new polyoxygenated cyclohexene derivative from <i>Artabotrys hainanensis</i> Jin-Ying Tang Yan-Ping Liu Peng-Kun Ju Xiu-Lan Luo Zhi-Jie Zhang Peng Ren Liang Lai Guang-Ying Chen Yan-Hui Fu 10.6084/m9.figshare.5579929.v1 https://tandf.figshare.com/articles/journal_contribution/A_new_polyoxygenated_cyclohexene_derivative_from_i_Artabotrys_hainanensis_i_/5579929 <p>A new polyoxygenated cyclohexene derivative, artahainanol A (<b>1</b>), together with three known analogues (<b>2</b>–<b>4</b>), was isolated from the stems and leaves of <i>Artabotrys hainanensis</i>. Among them, <b>1</b> is an unusual polyoxygenated cyclohexene containing 14 carbon atoms on the carbon skeleton. All known compounds (<b>2</b>–<b>4</b>) were isolated from the genus <i>Artabotrys</i> for the first time. The structure of <b>1</b> was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 <i>in vitro</i>. Compounds <b>1</b>–<b>4</b> showed significant inhibitory effects against various human cancer cell lines with IC<sub>50</sub> values ranging from 2.68 to 18.32 μM.</p> 2017-11-08 13:23:37 Artabotrys hainanensis polyoxygenated cyclohexene artahainanol A cytotoxicities