10.6084/m9.figshare.5579929.v1
Jin-Ying Tang
Jin-Ying
Tang
Yan-Ping Liu
Yan-Ping
Liu
Peng-Kun Ju
Peng-Kun
Ju
Xiu-Lan Luo
Xiu-Lan
Luo
Zhi-Jie Zhang
Zhi-Jie
Zhang
Peng Ren
Peng
Ren
Liang Lai
Liang
Lai
Guang-Ying Chen
Guang-Ying
Chen
Yan-Hui Fu
Yan-Hui
Fu
A new polyoxygenated cyclohexene derivative from <i>Artabotrys hainanensis</i>
Taylor & Francis Group
2017
Artabotrys hainanensis
polyoxygenated cyclohexene
artahainanol A
cytotoxicities
2017-11-08 13:23:37
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/A_new_polyoxygenated_cyclohexene_derivative_from_i_Artabotrys_hainanensis_i_/5579929
<p>A new polyoxygenated cyclohexene derivative, artahainanol A (<b>1</b>), together with three known analogues (<b>2</b>–<b>4</b>), was isolated from the stems and leaves of <i>Artabotrys hainanensis</i>. Among them, <b>1</b> is an unusual polyoxygenated cyclohexene containing 14 carbon atoms on the carbon skeleton. All known compounds (<b>2</b>–<b>4</b>) were isolated from the genus <i>Artabotrys</i> for the first time. The structure of <b>1</b> was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 <i>in vitro</i>. Compounds <b>1</b>–<b>4</b> showed significant inhibitory effects against various human cancer cell lines with IC<sub>50</sub> values ranging from 2.68 to 18.32 μM.</p>