10.6084/m9.figshare.5568079
Raj Kumar Thapa
Raj Kumar
Thapa
Hanh Thuy Nguyen
Hanh Thuy
Nguyen
Milan Gautam
Milan
Gautam
Aarajana Shrestha
Aarajana
Shrestha
Eung Seok Lee
Eung Seok
Lee
Sae Kwang Ku
Sae Kwang
Ku
Han-Gon Choi
Han-Gon
Choi
Chul Soon Yong
Chul Soon
Yong
Jong Oh Kim
Jong Oh
Kim
Hydrophobic binding peptide-conjugated hybrid lipid-mesoporous silica nanoparticles for effective chemo-photothermal therapy of pancreatic cancer
Taylor & Francis Group
2017
Bortezomib
hydrophobic-binding peptide
IR-820
pancreatic cancer
chemo-phototherapy
2017-11-03 10:32:02
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Hydrophobic_binding_peptide-conjugated_hybrid_lipid-mesoporous_silica_nanoparticles_for_effective_chemo-photothermal_therapy_of_pancreatic_cancer/5568079
<p>Nanoparticle-based drug delivery systems are designed to reach tumor sites based on their enhanced permeation and retention effects. However, a lack of interaction of these nanoparticles with cancer cells might lead to reduced uptake in the tumors, which might compromise the therapeutic efficacy of the system. Therefore, we developed bortezomib and IR-820-loaded hybrid-lipid mesoporous silica nanoparticles conjugated with the hydrophobic-binding peptide, cyclosporine A (CsA), and referred to them as CLMSN/BIR. Upon reaching the tumor site, CsA interacts hydrophobically with the cancer cell membranes to allow effective uptake of the nanoparticles. Nanoparticles ∼160 nm in size were prepared and the stability of IR-820 significantly improved. High cellular uptake of the nanoparticles was evident with pronounced apoptotic effects in PANC-1 and MIA PaCa-2 cells that were mediated by the chemotherapeutic effect of bortezomib and the photothermal and reactive oxygen species generation effects of IR-820. An <i>in vivo</i> biodistribution study indicated there was high accumulation in the tumor with an enhanced photothermal effect in PANC-1 xenograft mouse tumors. Furthermore, enhanced antitumor effects in PANC-1 xenograft tumors were observed with minimal toxicity induction in the organs of mice. Cumulatively, these results indicated the promising effects of CLMSN/BIR for effective chemo-phototherapy of pancreatic cancers.</p>