%0 Figure %A Scott, Aaron J. %A Song, Eun-Kee %A Bagby, Stacey %A Purkey, Alicia %A McCarter, Martin %A Gajdos, Csaba %A Quackenbush, Kevin S. %A Cross, Benjamin %A M. Pitts, Todd %A Choon Tan, Aik %A Eckhardt, S. Gail %A Fenton, Hubert %A Arcaroli, John %A A. Messersmith, Wells %D 2017 %T Evaluation of baseline pathway gene expression between sensitive and resistant CRC cell lines. %U https://plos.figshare.com/articles/figure/Evaluation_of_baseline_pathway_gene_expression_between_sensitive_and_resistant_CRC_cell_lines_/5560564 %R 10.1371/journal.pone.0187173.g005 %2 https://ndownloader.figshare.com/files/9657031 %K Src pathway %K anti-proliferative activity %K 72 hours %K 17 CRC explants %K Src expression %K dasatinib treatment %K CRC explants %K G 1 inhibition %K baseline increase %K anti-tumor effects %K Methods CRC cell lines %K 50 CRC cell lines %K tumor growth inhibition %K anti-invasive activity %K vivo efficacy %K G 1 cell cycle arrest %K sulforhodamine B %K explant mouse model Background Dysregulation %K FAK gene expression %K 17 patient-derived CRC explants %K SRB %K xenograft mouse model %K anti-tumor activity %K PDX %K patient-derived tumor explant %K Conclusion Dasatinib %K CRC cell lines %K TGI %K colorectal cancer cell lines %K IC %K 28 days %X

A) Pathway analysis of sensitive and resistant gene expression and KEGG pathway diagram shows that adherens junction is a pathway enriched in sensitive CRC cell lines (red shows the genes that are increased in the sensitive cell lines and include Src and FAK. B) Src and C) FAK gene expression are significantly elevated in sensitive when compared to resistant CRC cell lines.

%I PLOS ONE