10.1371/journal.pone.0187173.g005 Aaron J. Scott Aaron J. Scott Eun-Kee Song Eun-Kee Song Stacey Bagby Stacey Bagby Alicia Purkey Alicia Purkey Martin McCarter Martin McCarter Csaba Gajdos Csaba Gajdos Kevin S. Quackenbush Kevin S. Quackenbush Benjamin Cross Benjamin Cross Todd M. Pitts Todd M. Pitts Aik Choon Tan Aik Choon Tan S. Gail Eckhardt S. Gail Eckhardt Hubert Fenton Hubert Fenton John Arcaroli John Arcaroli Wells A. Messersmith Wells A. Messersmith Evaluation of baseline pathway gene expression between sensitive and resistant CRC cell lines. Public Library of Science 2017 Src pathway anti-proliferative activity 72 hours 17 CRC explants Src expression dasatinib treatment CRC explants G 1 inhibition baseline increase anti-tumor effects Methods CRC cell lines 50 CRC cell lines tumor growth inhibition anti-invasive activity vivo efficacy G 1 cell cycle arrest sulforhodamine B explant mouse model Background Dysregulation FAK gene expression 17 patient-derived CRC explants SRB xenograft mouse model anti-tumor activity PDX patient-derived tumor explant Conclusion Dasatinib CRC cell lines TGI colorectal cancer cell lines IC 28 days 2017-11-01 17:38:02 Figure https://plos.figshare.com/articles/figure/Evaluation_of_baseline_pathway_gene_expression_between_sensitive_and_resistant_CRC_cell_lines_/5560564 <p>A) Pathway analysis of sensitive and resistant gene expression and KEGG pathway diagram shows that adherens junction is a pathway enriched in sensitive CRC cell lines (red shows the genes that are increased in the sensitive cell lines and include Src and FAK. B) Src and C) FAK gene expression are significantly elevated in sensitive when compared to resistant CRC cell lines.</p>