10.1371/journal.pone.0187173.g005
Aaron J. Scott
Aaron J.
Scott
Eun-Kee Song
Eun-Kee
Song
Stacey Bagby
Stacey
Bagby
Alicia Purkey
Alicia
Purkey
Martin McCarter
Martin
McCarter
Csaba Gajdos
Csaba
Gajdos
Kevin S. Quackenbush
Kevin S.
Quackenbush
Benjamin Cross
Benjamin
Cross
Todd M. Pitts
Todd
M. Pitts
Aik Choon Tan
Aik
Choon Tan
S. Gail Eckhardt
S. Gail
Eckhardt
Hubert Fenton
Hubert
Fenton
John Arcaroli
John
Arcaroli
Wells A. Messersmith
Wells
A. Messersmith
Evaluation of baseline pathway gene expression between sensitive and resistant CRC cell lines.
Public Library of Science
2017
Src pathway
anti-proliferative activity
72 hours
17 CRC explants
Src expression
dasatinib treatment
CRC explants
G 1 inhibition
baseline increase
anti-tumor effects
Methods CRC cell lines
50 CRC cell lines
tumor growth inhibition
anti-invasive activity
vivo efficacy
G 1 cell cycle arrest
sulforhodamine B
explant mouse model Background Dysregulation
FAK gene expression
17 patient-derived CRC explants
SRB
xenograft mouse model
anti-tumor activity
PDX
patient-derived tumor explant
Conclusion Dasatinib
CRC cell lines
TGI
colorectal cancer cell lines
IC
28 days
2017-11-01 17:38:02
Figure
https://plos.figshare.com/articles/figure/Evaluation_of_baseline_pathway_gene_expression_between_sensitive_and_resistant_CRC_cell_lines_/5560564
<p>A) Pathway analysis of sensitive and resistant gene expression and KEGG pathway diagram shows that adherens junction is a pathway enriched in sensitive CRC cell lines (red shows the genes that are increased in the sensitive cell lines and include Src and FAK. B) Src and C) FAK gene expression are significantly elevated in sensitive when compared to resistant CRC cell lines.</p>