10.6084/m9.figshare.5539927.v1 Yan-Ping Liu Yan-Ping Liu Peng-Kun Ju Peng-Kun Ju Jin-Tao Long Jin-Tao Long Liang Lai Liang Lai Wan-Hui Zhao Wan-Hui Zhao Chao Zhang Chao Zhang Zhi-Jie Zhang Zhi-Jie Zhang Yan-Hui Fu Yan-Hui Fu Cytotoxic indole alkaloids from Nauclea orientalis Taylor & Francis Group 2017 Nauclea orientalis indole alkaloid nauclorienine cytotoxicities 2017-10-26 11:11:03 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Cytotoxic_indole_alkaloids_from_Nauclea_orientalis/5539927 <p>A new indole alkaloid, nauclorienine (<b>1</b>), along with seven known alkaloids (<b>2–8</b>), were isolated from the stems and leaves of <i>Nauclea orientalis</i>. Among them, nauclorienine (<b>1</b>) was a new indole alkaloid holding a rare corynanthe-type skeleton, and the known compounds (<b>2–8</b>) were isolated from <i>N. orientalis</i> for the first time. Their structures were elucidated on the basis of extensive spectroscopic data analyses. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 <i>in vitro</i>. Alkaloids <b>1–4</b> exhibited significant inhibitory effects against various human cancer cell lines with IC<sub>50</sub> values comparable to those of cisplatin.</p>