10.1371/journal.pone.0185980.g007
Basetti Madhu
Basetti
Madhu
Alexandra Jauhiainen
Alexandra
Jauhiainen
Sean McGuire
Sean
McGuire
John R. Griffiths
John R.
Griffiths
Metabolic interactions between brain tumour cells and host cells.
Public Library of Science
2017
brain tumour metabolism
HR-MAS 1 H NMR spectra Methods
glycolytic tumour cells
Additional metabolite exchanges
75 meningiomas
alanine
378 HRMAS 1 H NMR spectra
pre-necrotic tumour tissue
choline turnover
lipid signals
glutamine
tumour types
tumours co-opt
metabolite-metabolite correlation analysis
tCho
tCr pool
Warburg effect
phosphocreatine-driven glutamate uptake
37 oligodendrogliomas
host cells
catabolic metabolites
101 astrocytomas
mechanism
cytosolic lipid droplets
pairwise metabolite-metabolite correlation analysis
eTumour database
33 metastases
MMCA
lactate
2017-10-25 17:29:23
Figure
https://plos.figshare.com/articles/figure/Metabolic_interactions_between_brain_tumour_cells_and_host_cells_/5538550
<p>The lactate from tumour cell is transported to glial cells, where it is used a fuel to produce ATP. ATP and PCr are connected via the creatine-kinase reaction. PCr, phosphocreatine; Cr, creatine; TCA, tricarboxylic acid cycle.</p>