Supplementary Material for: Bevacizumab in Combination with Platinum-Based Chemotherapy in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with or without Brain Metastases: A French Cohort Study (EOLE)
Bennouna J.
Falchero L.
Schott R.
Bonnetain F.
Coudert M.
Ben Hadj Yahia B.
Chouaid C.
10.6084/m9.figshare.5531755.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Bevacizumab_in_Combination_with_Platinum-Based_Chemotherapy_in_Patients_with_Advanced_Non-Squamous_Non-Small_Cell_Lung_Cancer_with_or_without_Brain_Metastases_A_French_Cohort_Study_EOLE_/5531755
<p><b><i>Objectives:</i></b> The aim of this study was to describe the
characteristics of patients receiving bevacizumab plus first-line
metastatic chemotherapy for non-squamous advanced non-small cell lung
cancer (aNSCLC), with or without brain metastases, in routine clinical
practice. Other objectives were to describe treatment efficacy,
modalities of use, and safety. <b><i>Methods:</i></b> For this non-interventional, prospective, national, multicentre study, data were collected every 3 months over 18 months. <b><i>Results:</i></b>
Of the 407 patients analysed, 84 (21%) with brain metastases at
bevacizumab initiation had poorer general health than patients with no
brain metastases (Eastern Cooperative Oncology Group [ECOG] performance
status score = 2: 16 vs. 11%). All but 2 patients received bevacizumab
(7.5 or 15 mg/kg/3 weeks in 99% of patients) in combination with doublet
chemotherapy. Median progression-free survival and overall survival did
not differ significantly between patients with or without brain
metastases (6.5 months, 95% CI 5.7-8.1 vs. 6.9 months, 95% CI 5.9-7.6, <i>p</i> = 0.57; 14.5 months, 95% CI 10.0 vs. 12.5 months, 95% CI 10.1-14.7, <i>p</i>
= 0.33). In 30 and 32% of the patients, respectively, at least one
serious adverse event was reported, with a causal relationship to
bevacizumab in 20 and 21% of the patients. <b><i>Conclusion:</i></b>
This study confirmed in a real-life setting the safety profile and
survival benefits of first-line chemotherapy with bevacizumab in aNSCLC
patients with brain metastases.</p>
2017-10-24 09:34:39
Non-small cell lung carcinoma
Brain metastasis
Bevacizumab
Observational study
Overall survival