10.1371/journal.pgen.1000676.g003 Chia Huey Ooi Chia Huey Ooi Tatiana Ivanova Tatiana Ivanova Jeanie Wu Jeanie Wu Minghui Lee Minghui Lee Iain Beehuat Tan Iain Beehuat Tan Jiong Tao Jiong Tao Lindsay Ward Lindsay Ward Jun Hao Koo Jun Hao Koo Veena Gopalakrishnan Veena Gopalakrishnan Yansong Zhu Yansong Zhu Lai Ling Cheng Lai Ling Cheng Julian Lee Julian Lee Sun Young Rha Sun Young Rha Hyun Cheol Chung Hyun Cheol Chung Kumaresan Ganesan Kumaresan Ganesan Jimmy So Jimmy So Khee Chee Soo Khee Chee Soo Dennis Lim Dennis Lim Weng Hoong Chan Weng Hoong Chan Wai Keong Wong Wai Keong Wong David Bowtell David Bowtell Khay Guan Yeoh Khay Guan Yeoh Heike Grabsch Heike Grabsch Alex Boussioutas Alex Boussioutas Patrick Tan Patrick Tan Patterns of pathway activation in gastric cancer cell lines. Public Library of Science 2009 pathway activation gastric cancer 2009-10-02 00:42:53 Figure https://plos.figshare.com/articles/figure/_Patterns_of_pathway_activation_in_gastric_cancer_cell_lines_/552573 <p>Twenty gene expression signatures representing 11 cancer-related pathways (previously described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000676#pgen-1000676-g002" target="_blank">Figure 2</a>) were queried against a panel of 25 gastric cancer cell lines. The heatmap depicts the activation scores of pathways represented by the signatures (rows) in individual cell lines (columns), with red squares denoting higher activation scores. Pathways and cell lines were ordered using unsupervised hierarchical clustering. Similar to primary tumors, pathways related to proliferation or stem cell form a distinct cluster (brown) from other pathways (grey). Cell lines with high predicted activation of NF-κB, Wnt/β-catenin, or proliferation/stem cell-related pathways are indicated by relevant color bars at the bottom of the heatmap. For the proliferation/stem cell-related signatures, the cell lines were mean-normalized relative to one another against the mean activation score, as all cell lines scored positive for proliferation/stem cell-related pathways.</p>