10.1371/journal.pgen.1000676.g003
Chia Huey Ooi
Chia
Huey Ooi
Tatiana Ivanova
Tatiana
Ivanova
Jeanie Wu
Jeanie
Wu
Minghui Lee
Minghui
Lee
Iain Beehuat Tan
Iain
Beehuat Tan
Jiong Tao
Jiong
Tao
Lindsay Ward
Lindsay
Ward
Jun Hao Koo
Jun
Hao Koo
Veena Gopalakrishnan
Veena
Gopalakrishnan
Yansong Zhu
Yansong
Zhu
Lai Ling Cheng
Lai
Ling Cheng
Julian Lee
Julian
Lee
Sun Young Rha
Sun
Young Rha
Hyun Cheol Chung
Hyun
Cheol Chung
Kumaresan Ganesan
Kumaresan
Ganesan
Jimmy So
Jimmy
So
Khee Chee Soo
Khee Chee
Soo
Dennis Lim
Dennis
Lim
Weng Hoong Chan
Weng Hoong
Chan
Wai Keong Wong
Wai Keong
Wong
David Bowtell
David
Bowtell
Khay Guan Yeoh
Khay Guan
Yeoh
Heike Grabsch
Heike
Grabsch
Alex Boussioutas
Alex
Boussioutas
Patrick Tan
Patrick
Tan
Patterns of pathway activation in gastric cancer cell lines.
Public Library of Science
2009
pathway
activation
gastric
cancer
2009-10-02 00:42:53
Figure
https://plos.figshare.com/articles/figure/_Patterns_of_pathway_activation_in_gastric_cancer_cell_lines_/552573
<p>Twenty gene expression signatures representing 11 cancer-related pathways (previously described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000676#pgen-1000676-g002" target="_blank">Figure 2</a>) were queried against a panel of 25 gastric cancer cell lines. The heatmap depicts the activation scores of pathways represented by the signatures (rows) in individual cell lines (columns), with red squares denoting higher activation scores. Pathways and cell lines were ordered using unsupervised hierarchical clustering. Similar to primary tumors, pathways related to proliferation or stem cell form a distinct cluster (brown) from other pathways (grey). Cell lines with high predicted activation of NF-κB, Wnt/β-catenin, or proliferation/stem cell-related pathways are indicated by relevant color bars at the bottom of the heatmap. For the proliferation/stem cell-related signatures, the cell lines were mean-normalized relative to one another against the mean activation score, as all cell lines scored positive for proliferation/stem cell-related pathways.</p>