Supplementary Material for: Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers
Liu F.
Dong Q.
Huang J.
10.6084/m9.figshare.5505322.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Overexpression_of_LncRNA_PVT1_Predicts_Advanced_Clinicopathological_Features_and_Serves_as_an_Unfavorable_Risk_Factor_for_Survival_of_Patients_with_Gastrointestinal_Cancers/5505322
<p><b><i>Background/Aims:</i></b> Many studies have reported that PVT1
played important roles in diverse cancer types. But the systematic
analysis of PVT1 in gastrointestinal cancers has not been inspected.
Thus, we aimed to investigate clinical value of the long noncoding RNA
PVT1 (lncRNA) expression in digestive system cancers. <b><i>Methods:</i></b>
Eligible studies were collected from a number of databases (PubMed, Web
of Science, Embase, Chinese National Knowledge Infrastructure and
Wanfang database). Pooled hazard ratio (HR) or odds ratio (OR) with 95 %
confidence interval (95 % Cl) were applied to assess the clinical
significance of PVT1. <b><i>Results:</i></b> Data from 15 articles were
included with a total of 2585 patients. Elevated PVT1 expression were
significantly related to poor overall survival (OS) [HR = 1.86, 95% CI
(1.44, 2.28); p<0. 0001] in digestive system cancers. The same
association was also observed between PVT1 expression with outcomes,
including disease free survival (DFS), disease specific survival (DSS)
and relapse free survival (RFS). The lncRNA PVT1 could also be
predicative for some clinicopathological features. <b><i>Conclusions:</i></b>
This meta-analysis revealed that PVT1 may serve as a prognostic
predictor and pathological biomarker in digestive system cancers.</p>
2017-10-17 12:26:43
Pvt1
LncRNA
Digestive system cancer
Pathological features
Prognosis