TY - DATA T1 - Effect of trans-factor binding on RNA processing shifts. PY - 2017/10/12 AU - Allison L. Richards AU - Donovan Watza AU - Anthony Findley AU - Adnan Alazizi AU - Xiaoquan Wen AU - Athma A. Pai AU - Roger Pique-Regi AU - Francesca Luca UR - https://plos.figshare.com/articles/figure/Binding_of_ELF2_impacts_AFE_shift_following_selenium_treatment_/5496982 DO - 10.1371/journal.pgen.1006995.g005 L4 - https://ndownloader.figshare.com/files/9666055 KW - AFE QTL mapping KW - SNP KW - RNA processing events KW - shift KW - ETS KW - FDR KW - trans factors KW - binding KW - response KW - RNA processing Environmental perturbations KW - ELF 2 factor KW - RNA processing N2 - A) and D) show models of hypothesized mechanism of splicing or transcription factor influence on RNA processing and exon usage. B) An example of a correlation between the changes in gene expression of an RNA processing factor (LARP7) and the percent of RIs that shift towards the intron retention across all environments for which gene expression could be assessed. E) An example of a correlation between the changes in gene expression of a transcription factor (HSF1) and the percent of AFEs that shift towards the upstream AFE across all environments for which gene expression could be assessed. The correlation for B) and E) was tested using Spearman’s rho and the p-value shown is Benjamini-Hochberg corrected while the trendline depicts the best-fit line. C) Graph indicating the predictability (AUC as a proxy) of SE or RI shifts in a certain environment given predicted splicing factor binding sites (RNAcompete). F) Graph indicating the predictability (AUC as a proxy) of AFE shifts in a certain environment given transcription factor footprints [48]. ER -