%0 Journal Article %A Zhang, Liuhong %A Niaz, Shah Iram %A Wang, Zhen %A Zhu, Yonghong %A Lin, Yongcheng %A Li, Jing %A Liu, Lan %D 2017 %T α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307 %U https://tandf.figshare.com/articles/journal_contribution/_-Glucosidase_inhibitory_and_cytotoxic_botryorhodines_from_mangrove_endophytic_fungus_i_Trichoderma_i_sp_307/5492725 %R 10.6084/m9.figshare.5492725.v1 %2 https://ndownloader.figshare.com/files/9500710 %K Botryorhodine H %K Trichoderma sp %K endophytic fungus %K α-glucosidase inhibitory activity %K cytotoxicity %X

One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (24), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 13 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 μM).

%I Taylor & Francis