COSMIC2 – A science gateway for cryo-electron microscopy CianfroccoMichael WongMona YounChoonhan 2017 Recent advances in cryo-electron microscopy (cryo-EM) have led to the wide-spread adoption of the technique worldwide to allow the determination of atomic protein structures. In order to use this powerful technique, however, scientists must use high performance computing resources in order to calculate protein structures from terabytes of image data. We have built the COSMIC<sup>2</sup> science gateway to provide researchers with access to the computing resources available on the Comet supercomputer located at the San Diego Supercomputer Center. In order to handle terabyte-sized data uploads, we have integrated the file transfer service Globus into the gateway. During this demonstration, we will highlight the user interface and data ingestion process used by the gateway, while also discussing considerations for user interface and design.