Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel – A comparative study M. Meera A. Ruckmani R. Saravanan R. Lakshmipathy prabhu 10.6084/m9.figshare.5481067.v1 https://tandf.figshare.com/articles/journal_contribution/Anti-inflammatory_effect_of_ethanolic_extract_of_spine_skin_and_rind_of_Jack_fruit_peel_A_comparative_study/5481067 <p>The present study was conducted to identify the chemical constituents and evaluate the anti-inflammatory activity of crude ethanolic extracts of spine, skin and rind of jack fruit (<i>Artocarpus heterophyllus</i>) peel. Polyphenol and flavonoid contents were assessed using Folin’s Ciocalteu reagent and aluminium chloride methods which revealed 316, 355 and 382 mg tannic acid equivalent/g of polyphenol and 96.7, 131.6 and 164.6 mg quercetin equivalent/g of flavonoid in spine, skin and rind, respectively. Anti-inflammatory activity of all three extracts was comparable to diclofenac <i>in vitro</i> and <i>in vivo</i> studies<i>.</i> Skin exhibited maximum anti-inflammatory activity, rind had preferential inhibition on Cyclooxygenase-2 and spine and skin inhibited both Cyclooxygenase-1 and 2 <i>in vitro</i>.</p> 2017-10-09 12:52:59 Artocarpus heterophyllus polyphenols COX-1 COX-2 anti-inflammatory peel extract