10.6084/m9.figshare.5469115.v1
Jilg C.A.
Jilg
C.A.
Drendel V.
Drendel
V.
Bacher J.
Bacher
J.
Pisarski P.
Pisarski
P.
Neeff H.
Neeff
H.
Drognitz O.
Drognitz
O.
Schwardt M.
Schwardt
M.
Gläsker S.
Gläsker
S.
Malinoc A.
Malinoc
A.
Erlic Z.
Erlic
Z.
Nunez M.
Nunez
M.
Weber A.
Weber
A.
Azurmendi P.
Azurmendi
P.
Schultze-Seemann W.
Schultze-Seemann
W.
Werner M.
Werner
M.
Neumann H.P.H.
Neumann
H.P.H.
Supplementary Material for: Autosomal Dominant Polycystic Kidney Disease: Prevalence of Renal Neoplasias in Surgical Kidney Specimens
Karger Publishers
2017
Adult polycystic renal disease
Renal cell carcinoma
Renal cell cancer
Autosomal dominant polycystic kidney disease
2017-10-04 12:28:24
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Autosomal_Dominant_Polycystic_Kidney_Disease_Prevalence_of_Renal_Neoplasias_in_Surgical_Kidney_Specimens/5469115
<p><b><i>Background:</i></b> The role of autosomal dominant polycystic
kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC)
is still under discussion. Data on prevalence of RCC in ADPKD are
limited, especially on a large population scale. The aim of this study
was to analyze the prevalence of RCC in ADPKD kidneys and characterize
the clinical features of this coincidence. <b><i>Methods:</i></b> Based
on our histopathological registry for ADPKD and the Else
Kröner-Fresenius Registry, we retrospectively reviewed malignant and
benign renal lesions in patients with ADPKD who had undergone renal
surgery from 1988 to 2011. <b><i>Results:</i></b> 240 ADPKD patients
underwent 301 renal surgeries. Mean age at surgery was 54 years.
Overall, 16 malignant and 11 benign lesions were analyzed in 301 kidneys
(5.3%; 3.7%), meaning that 12/240 (5%; 1:20) patients presented with
malignant renal lesions. 66.7% (8/12) of these patients had undergone
dialysis prior to surgery. We found 10/16 (63%) papillary RCC, 5/16
(31%) clear cell RCC, and 1/16 (6%) papillary noninvasive urothelial
cancer. Regarding all renal lesions, 6/17 (35.3%) patients had more than
one histological finding in their kidneys. In 2 cases, metachronous
metastases were removed. Mean follow-up was 66.7 months. <b><i>Conclusion:</i></b>
Kidney-related prevalence of RCC in ADPKD kidneys was surprisingly
high. Whether or not this is due to chronic dialysis or due to the
underlying disease is still speculative. Like other cystic renal
diseases with an increased risk for RCC, the attending physician should
be aware of the malignant potential of ADPKD, especially with
concomitant dialysis.</p>