Additional file 1: Figure S1. of S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis Niels Cremers Martijn H. J. van den Bosch Stephanie van Dalen Irene Di Ceglie Giuliana Ascone Fons van de Loo Marije Koenders Peter van der Kraan Annet Sloetjes Thomas Vogl Johannes Roth Edwin Geven Arjen Blom Peter van Lent 10.6084/m9.figshare.c.3894754_D1.v1 https://springernature.figshare.com/articles/presentation/Additional_file_1_Figure_S1_of_S100A8_A9_increases_the_mobilization_of_pro-inflammatory_Ly6Chigh_monocytes_to_the_synovium_during_experimental_osteoarthritis/5462896 S100A8/A9 protein levels are systemically elevated in the serum during early CiOA. Systemic levels of S100A8/A9 protein in serum of WT mice are increased early during CiOA compared to saline-injected control mice, measured using ELISA. Data represent mean ± SD of five individual mice per group per time point. *Significantly different from saline-injected control (*p < 0.05, **p < 0.01, ***p < 0.001). Figure S2. Expression of adhesion molecules is lower in the BM of WT mice, compared to S100a9-/- mice, at CiOA day 7. mRNA expression of several adhesion molecules is lower in the BM of S100a9-/- mice compared to WT mice at CiOA day 7. Data represent mean ± SD of five individual mice. *Significantly different from saline-injected control (*p < 0.05, **p < 0.01, ***p < 0.001). (PPT 142 kb) 2017-09-29 05:00:00 S100 Mobilization Ly6C high/low monocytes Systemic effects Collagenase-induced osteoarthritis