TY - DATA T1 - Supplementary Material for: Lymphopenia and CD4+/CD8+ Cell Reduction under Fumaric Acid Esters PY - 2017/09/27 AU - Sondermann W. AU - Rompoti N. AU - Leister L. AU - Huptas L. AU - Klode J. AU - Dissemond J. AU - Körber A. UR - https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Lymphopenia_and_CD4_CD8_Cell_Reduction_under_Fumaric_Acid_Esters/5446441 DO - 10.6084/m9.figshare.5446441.v1 L4 - https://ndownloader.figshare.com/files/9415681 KW - Psoriasis KW - Fumaric acid esters KW - Lymphopenia KW - T cells KW - CD4+ and CD8+ cells N2 - Background: Fumaric acid esters (FAEs) are a broadly used therapy option for patients suffering from moderate-to-severe plaque psoriasis. Various studies in psoriasis have already shown peripheral blood lymphopenia during oral FAE therapy. Smaller studies also documented a reduction of CD4+ and CD8+ cell counts. Up to now, there are few case reports on opportunistic infections under FAE therapy - all of them associated with lymphopenia. Objective: To examine the influence of FAEs on white blood cells with special regard to leukocytes, lymphocytes, and CD4+ and CD8+ cells during psoriasis therapy. Patients and Methods: A cohort of 105 patients with diagnosed moderate-to-severe chronic plaque psoriasis was enrolled in this single-centre observational trial. For a cohort of 36 patients, T-cell subset analyses were performed. Results: Of the total, 65 patients were male (61.9%) and 40 (38.1%) female; the mean age was 43.3 years (range 16-73 years). The median lymphocyte count was significantly reduced by about 35.8% after the first 6 months of therapy. When assessing the lymphocyte count nadir over the whole period observed, 46.7% of the patients developed lymphopenia. Severe lymphopenia (<500/µL) was documented in 11.4% of the patients. The CD4+ and CD8+ cell counts were significantly reduced by about 30.2 and 45.3%, respectively. Conclusion: To the best of our knowledge this is the largest clinical investigation analysing prospectively CD4+ and CD8+ cell counts in psoriasis patients receiving FAEs. We suggest periodic monitoring of absolute lymphocyte counts as well as the establishment of the determination of T-cell subsets prior to and during therapy. ER -