%0 Journal Article %A Abdelraheem, Eman M. M. %A de Haan, Michel P. %A Patil, Pravin %A Kurpiewska, Katarzyna %A Kalinowska-Tłuścik, Justyna %A Shaabani, Shabnam %A Dömling, Alexander %D 2017 %T Concise Synthesis of Tetrazole Macrocycle %U https://acs.figshare.com/articles/journal_contribution/Concise_Synthesis_of_Tetrazole_Macrocycle/5402194 %R 10.1021/acs.orglett.7b02319.s001 %2 https://ndownloader.figshare.com/files/9305893 %K macrocycle %K Tetrazole Macrocycle %K Concise Synthesis %K isocyanocarboxylicacid esters %K α- isocyano -ω-amines %K step synthesis %K Ugi tetrazole reaction %K chemoselective amidation %X A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo an Ugi tetrazole reaction to close the macrocycle. Advantageously, this strategy allows short access to 11–19-membered macrocycles in which substituents can be independently varied at three different positions. %I ACS Publications