Shi, Shu-Qin Fan, Yao-Yue Xu, Cheng-Hui Ding, Jian Wang, Guan-Wu Yue, Jian-Min Cytotoxic 8,9-<i>seco</i>-ent-kaurane diterpenoids from <i><i>Croton kongensis</i></i> <p>Chemical study on the ethanolic extract generated from the aerial parts of <i>Croton kongensis</i> led to the isolation of three new 8,9-<i>seco</i>-ent-kaurane diterpenoids, kongeniods A‒C (<b>1</b>‒<b>3</b>), together with seven known analogs (<b>4</b>–<b>10</b>). The structures of these compounds were assigned by spectroscopic data analysis. The <i>vitro</i> cytotoxic tests showed that compounds <b>1</b>–<b>3</b> exhibited strong activities against HL-60 cell lines with IC<sub>50</sub> values of 0.47, 0.58, and 1.27 μM, respectively.</p> Croton kongensis;8,9-seco-ent-kaurane;diterpenoids;cytotoxicity 2017-09-12
    https://tandf.figshare.com/articles/journal_contribution/Cytotoxic_8_9-_i_seco_i_-ent-kaurane_diterpenoids_from_i_i_Croton_kongensis_i_i_/5398375
10.6084/m9.figshare.5398375.v1