TY - DATA T1 - Facile expeditious one-pot synthesis and antifungal evaluation of disubstituted 1,2,3-triazole with two amide linkages PY - 2017/11/08 AU - C. P. Kaushik AU - Raj Luxmi UR - https://tandf.figshare.com/articles/journal_contribution/A_facile_expeditious_one_pot_synthesis_and_antifungal_evaluation_of_disubstituted_1_2_3-triazole_with_two_amide_linkages/5352841 DO - 10.6084/m9.figshare.5352841 L4 - https://ndownloader.figshare.com/files/9198388 KW - 1,3-Dipolar cycloaddition KW - 1,4-disubstituted 1,2,3-triazoles KW - antifungal activity KW - synthesis N2 - A library of twenty five amide linked 1,4-disubstituted 1,2,3-triazoles have been prepared through a facile expeditious synthetic protocol involving Cu(I) mediated cyclization of N-(2-methylbut-3-yn-2-yl)aromatic amides and in situ generated 2-azido-N-substituted propanamides. Structures of newly synthesized compounds (5a–5y) were confirmed by analytical techniques, such as FTIR, 1H NMR, 13C NMR, and HRMS. In vitro antifungal activity was also examined against two fungal strains Candida albicans and Aspergillus niger by serial dilution method. The compounds 5 m and 5w exhibited appreciable potent activity. ER -