TY - DATA T1 - Supplementary Material for: S100A8/A9 (Calprotectin), Interleukin-6, and C-Reactive Protein in Obesity and Diabetes before and after Roux-en-Y Gastric Bypass Surgery PY - 2017/08/25 AU - Lylloff L. AU - Bathum L. AU - Madsbad S. AU - Grundtvig J.L.G. AU - Nordgaard-Lassen I. AU - Fenger M. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_S100A8_A9_Calprotectin_Interleukin-6_and_C-Reactive_Protein_in_Obesity_and_Diabetes_before_and_after_Roux-en-Y_Gastric_Bypass_Surgery/5346190 DO - 10.6084/m9.figshare.5346190.v1 L4 - https://ndownloader.figshare.com/files/9182992 KW - Inflammation KW - Diabetes mellitus type 2 KW - Obesity KW - Bariatric surgery N2 - Background: In obesity, which is a major contributor to insulin resistance and diabetes, the circulating level of S100A8/A9 (calprotectin) is elevated and declines after Roux-en-Y gastric bypass surgery (RYGB). However, studies on S100A8/A9 and the pathophysiological mechanisms in insulin resistance and diabetes are few and contradictory. Methods: We studied 48 subjects who underwent RYGB, comprising a non-diabetic control group and two diabetic groups in whom diabetes either regressed or persisted, 6-12 months post-surgically. S100A8/A9, interleukin 6 (IL-6) as well as other inflammatory and diabetes-related markers were measured pre- and post-surgically. Results: Significant and similar decreases of BMI were found in all groups. S100A8/A9 and IL-6 decreased significantly in the group with diabetes remission and in the control group, but not in the group with persistent diabetes. The relative changes in S100A8/A9 and IL-6 correlated significantly (r = 0.905, p = 0.005) only in the group with persistent diabetes. In contrast, leukocyte count and C-reactive protein correlated significantly to S100A8/A9 only in the control group. Conclusion: Our study is suggestive of S100A8/A9 and IL-6 being related to a persistent diabetes status post-surgically and of different pathophysiological mechanisms being involved in the post-surgical changes in the three groups, despite similar decreases in BMI. ER -