TY - DATA T1 - Supplementary Material for: The Impact of Treatment Preferences in Second-Line Chemotherapy on the Prognosis of HER2-Negative Metastatic Breast Cancer PY - 2017/08/25 AU - Mukai H. AU - Hagiwara Y. AU - Imi K. AU - Isaka H. AU - Watanabe K. AU - Matsuyama Y. AU - for the SELECT BC Study Group UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Impact_of_Treatment_Preferences_in_Second-Line_Chemotherapy_on_the_Prognosis_of_HER2-Negative_Metastatic_Breast_Cancer/5346181 DO - 10.6084/m9.figshare.5346181.v1 L4 - https://ndownloader.figshare.com/files/9182989 KW - SELECT BC study KW - First-line chemotherapy KW - Second-line chemotherapy KW - Inverse probability weighting estimation N2 - Objective: We assessed the impact of treatment preferences in second-line chemotherapy on breast cancer prognosis using the SELECT BC study. Methods: The SELECT BC study was performed in patients with HER2-negative metastatic breast cancer treated with initial chemotherapy. From these patients, 618 were assigned to 2 groups (S-1 group, 309; taxane group, 309). The S-1 and taxane groups were each subdivided into 3 groups: crossover group, protocol-recommended group, and other group, and the analysis of overall survival (OS) was performed using Cox regression with inverse probability weighting, to adjust for postrandomization confounding. Results: In the taxane group, the OS of the crossover group (39.6 months) was better than that of the protocol-recommended group (35.7 months) and the other chemotherapy group (36.9 months) (vs. the protocol-recommended group, HR 0.72 [95% CI 0.52-0.98], p = 0.037; vs. the other chemotherapy group, HR 0.71 [95% CI 0.43-1.18], p = 0.183). In the S-1 group, there was no statistically significant difference in OS between the 3 groups. Conclusion: The study of the combination of first-line chemotherapy and second-line chemotherapy showed that S-1 might be recommended as a second-line chemotherapy in patients in whom taxane was the primary chemotherapy. ER -