TY - DATA T1 - Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes PY - 2017/08/24 AU - Shang Gao AU - Hao Liu AU - Chi Yang AU - Zhiyuan Fu AU - Hequan Yao AU - Aijun Lin UR - https://acs.figshare.com/articles/journal_contribution/Accessing_1_3-Dienes_via_Palladium-Catalyzed_Allylic_Alkylation_of_Pronucleophiles_with_Skipped_Enynes/5345074 DO - 10.1021/acs.orglett.7b01960.s001 L4 - https://ndownloader.figshare.com/files/9181111 KW - atom economy KW - regioselectivitie KW - D 2 O KW - diene KW - cosolvent KW - Skipped Enynes KW - array KW - pronucleophile KW - enyne KW - access KW - palladium-catalyzed allylic alkylation KW - method KW - preinstall KW - efficiency KW - Accessing KW - scalability KW - oxidant KW - unactivated KW - group tolerance KW - deuterium KW - Diene KW - Palladium-Catalyzed Allylic Alkylation KW - Pronucleophile N2 - An unprecedented palladium-catalyzed allylic alkylation of pronucleophiles with unactivated skipped enynes has been developed. This method provides a straightforward access to a wide array of 1,3-dienes without the need to preinstall leaving groups or employ extra oxidants. The reaction exhibited high atom economy, good functional group tolerance, excellent regioselectivities, and scalability. With D2O as cosolvent, deuterium could be incorporated in high efficiency. ER -