10.1371/journal.pbio.2002257.g007 Yuanyuan Xie Yuanyuan Xie Dan Kaufmann Dan Kaufmann Matthew J. Moulton Matthew J. Moulton Samin Panahi Samin Panahi John A. Gaynes John A. Gaynes Harrison N. Watters Harrison N. Watters Dingxi Zhou Dingxi Zhou Hai-Hui Xue Hai-Hui Xue Camille M. Fung Camille M. Fung Edward M. Levine Edward M. Levine Anthea Letsou Anthea Letsou K. C. Brennan K. C. Brennan Richard I. Dorsky Richard I. Dorsky Correlation analysis in the human hypothalamus. Public Library of Science 2017 mouse show animal species Lef 1 Lef 1-dependent anxiolytic pathways zebrafish transcription factor animal kingdom circuit development 2 species Lef 1-dependent genes neuroendocrine organs Lef 1-dependent gene expression 2017-08-24 17:29:57 Figure https://plos.figshare.com/articles/figure/Correlation_analysis_in_the_human_hypothalamus_/5341639 <p>(A-G) Pearson correlations for hypothalamic gene expression among 96 postmortem human samples obtained from the Genotype-Tissue Expression (GTEx) project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002257#pbio.2002257.ref039" target="_blank">39</a>]. All the Pearson’s <i>r</i> and <i>P</i> values were calculated between 2 genes, and displayed in the graphs or tables after sorting by <i>r</i> values. Correlation expression profiles are shown for gene pairs <i>Pro-melanin concentrating hormone</i> (<i>PMCH</i>) versus <i>LEF1</i> (A), <i>Corticotropin-releasing hormone binding protein</i> (<i>CRHBP</i>) versus <i>LEF1</i> (B), <i>CRHBP</i> versus <i>PMCH</i> (F), and <i>Agouti-related protein</i> (<i>AGRP</i>) versus <i>Neuropeptide Y</i> (<i>NPY</i>) (G), with reads per kilobase of transcript per million mapped reads (RPKM) at log<sub>10</sub> scale used on both axes. Note that 1 data point (<i>NPY</i>: 0.1395; <i>AGRP</i>: 0) was not included in (G) due to the inability of plotting a 0 value on the logarithmic axis. Three tables of correlated genes for <i>LEF1</i> (C), <i>CRHBP</i> (D), and <i>PMCH</i> (E) list the top 9 positively correlated genes plus selected genes, including those involved in canonical Wnt signaling labeled in red. See the full list in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002257#pbio.2002257.s014" target="_blank">S8 Table</a>.</p>