10.1371/journal.pbio.2002257.g007
Yuanyuan Xie
Yuanyuan
Xie
Dan Kaufmann
Dan
Kaufmann
Matthew J. Moulton
Matthew
J. Moulton
Samin Panahi
Samin
Panahi
John A. Gaynes
John
A. Gaynes
Harrison N. Watters
Harrison N.
Watters
Dingxi Zhou
Dingxi
Zhou
Hai-Hui Xue
Hai-Hui
Xue
Camille M. Fung
Camille
M. Fung
Edward M. Levine
Edward
M. Levine
Anthea Letsou
Anthea
Letsou
K. C. Brennan
K. C.
Brennan
Richard I. Dorsky
Richard I.
Dorsky
Correlation analysis in the human hypothalamus.
Public Library of Science
2017
mouse show
animal species
Lef 1
Lef 1-dependent
anxiolytic pathways
zebrafish
transcription factor
animal kingdom
circuit development
2 species
Lef 1-dependent genes
neuroendocrine organs
Lef 1-dependent gene expression
2017-08-24 17:29:57
Figure
https://plos.figshare.com/articles/figure/Correlation_analysis_in_the_human_hypothalamus_/5341639
<p>(A-G) Pearson correlations for hypothalamic gene expression among 96 postmortem human samples obtained from the Genotype-Tissue Expression (GTEx) project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002257#pbio.2002257.ref039" target="_blank">39</a>]. All the Pearson’s <i>r</i> and <i>P</i> values were calculated between 2 genes, and displayed in the graphs or tables after sorting by <i>r</i> values. Correlation expression profiles are shown for gene pairs <i>Pro-melanin concentrating hormone</i> (<i>PMCH</i>) versus <i>LEF1</i> (A), <i>Corticotropin-releasing hormone binding protein</i> (<i>CRHBP</i>) versus <i>LEF1</i> (B), <i>CRHBP</i> versus <i>PMCH</i> (F), and <i>Agouti-related protein</i> (<i>AGRP</i>) versus <i>Neuropeptide Y</i> (<i>NPY</i>) (G), with reads per kilobase of transcript per million mapped reads (RPKM) at log<sub>10</sub> scale used on both axes. Note that 1 data point (<i>NPY</i>: 0.1395; <i>AGRP</i>: 0) was not included in (G) due to the inability of plotting a 0 value on the logarithmic axis. Three tables of correlated genes for <i>LEF1</i> (C), <i>CRHBP</i> (D), and <i>PMCH</i> (E) list the top 9 positively correlated genes plus selected genes, including those involved in canonical Wnt signaling labeled in red. See the full list in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002257#pbio.2002257.s014" target="_blank">S8 Table</a>.</p>