Zhang, Muliang Xi, Junwei Ruzi, Rehanguli Li, Nan Wu, Zhongkai Li, Weipeng Zhu, Chengjian Domino-Fluorination–Protodefluorination Enables Decarboxylative Cross-Coupling of α‑Oxocarboxylic Acids with Styrene via Photoredox Catalysis Domino-fluorination–protodefluorination decarboxylative cross-coupling of α-keto acids with styrene has been developed via photoredox catalysis. The critical part of this strategy is the formation of the carbon–fluorine (C–F) bond by the capture of a carbon-centered radical intermediate, which will overcome side reactions during the styrene radical functionalization process. Experimental studies have provided evidence indicating a domino-fluorination–protodefluorination pathway with α-keto acid initiating the photoredox cycle. The present catalytic protocol also affords a novel approach for the construction of α,β-unsaturated ketones under mild conditions. Photoredox;Styrene;cross-coupling;evidence;α- keto acid;Domino-fluorination;novel approach;Experimental studies;Decarboxylative;photoredox catalysis;Enable;Catalysi;styrene;α- keto acids;strategy;Domino-Fluorination;decarboxylative;construction;carbon-centered;side reactions;Cross-Coupling;domino-fluorination;formation;photoredox cycle;Oxocarboxylic;ketone;functionalization process;pathway;Acid;bond 2017-08-15
    https://acs.figshare.com/articles/journal_contribution/Domino-Fluorination_Protodefluorination_Enables_Decarboxylative_Cross-Coupling_of_Oxocarboxylic_Acids_with_Styrene_via_Photoredox_Catalysis/5340916
10.1021/acs.joc.7b01054.s001