Domino-Fluorination–Protodefluorination Enables Decarboxylative Cross-Coupling of α‑Oxocarboxylic Acids with Styrene via Photoredox Catalysis Muliang Zhang Junwei Xi Rehanguli Ruzi Nan Li Zhongkai Wu Weipeng Li Chengjian Zhu 10.1021/acs.joc.7b01054.s001 https://acs.figshare.com/articles/journal_contribution/Domino-Fluorination_Protodefluorination_Enables_Decarboxylative_Cross-Coupling_of_Oxocarboxylic_Acids_with_Styrene_via_Photoredox_Catalysis/5340916 Domino-fluorination–protodefluorination decarboxylative cross-coupling of α-keto acids with styrene has been developed via photoredox catalysis. The critical part of this strategy is the formation of the carbon–fluorine (C–F) bond by the capture of a carbon-centered radical intermediate, which will overcome side reactions during the styrene radical functionalization process. Experimental studies have provided evidence indicating a domino-fluorination–protodefluorination pathway with α-keto acid initiating the photoredox cycle. The present catalytic protocol also affords a novel approach for the construction of α,β-unsaturated ketones under mild conditions. 2017-08-15 00:00:00 Photoredox Styrene cross-coupling evidence α- keto acid Domino-fluorination novel approach Experimental studies Decarboxylative photoredox catalysis Enable Catalysi styrene α- keto acids strategy Domino-Fluorination decarboxylative construction carbon-centered side reactions Cross-Coupling domino-fluorination formation photoredox cycle Oxocarboxylic ketone functionalization process pathway Acid bond