Domino-Fluorination–Protodefluorination
Enables Decarboxylative Cross-Coupling of α‑Oxocarboxylic
Acids with Styrene via Photoredox Catalysis
Muliang Zhang
Junwei Xi
Rehanguli Ruzi
Nan Li
Zhongkai Wu
Weipeng Li
Chengjian Zhu
10.1021/acs.joc.7b01054.s001
https://acs.figshare.com/articles/journal_contribution/Domino-Fluorination_Protodefluorination_Enables_Decarboxylative_Cross-Coupling_of_Oxocarboxylic_Acids_with_Styrene_via_Photoredox_Catalysis/5340916
Domino-fluorination–protodefluorination
decarboxylative
cross-coupling of α-keto acids with styrene has been developed
via photoredox catalysis. The critical part of this strategy is the
formation of the carbon–fluorine (C–F) bond by the capture
of a carbon-centered radical intermediate, which will overcome side
reactions during the styrene radical functionalization process. Experimental
studies have provided evidence indicating a domino-fluorination–protodefluorination
pathway with α-keto acid initiating the photoredox cycle. The
present catalytic protocol also affords a novel approach for the construction
of α,β-unsaturated ketones under mild conditions.
2017-08-15 00:00:00
Photoredox
Styrene
cross-coupling
evidence
α- keto acid
Domino-fluorination
novel approach
Experimental studies
Decarboxylative
photoredox catalysis
Enable
Catalysi
styrene
α- keto acids
strategy
Domino-Fluorination
decarboxylative
construction
carbon-centered
side reactions
Cross-Coupling
domino-fluorination
formation
photoredox cycle
Oxocarboxylic
ketone
functionalization process
pathway
Acid
bond