Liu, Xin Hu, Ya-Jian Chen, Bo Min, Long Peng, Xiao-Shui Zhao, Jing Li, Shaoping N. C. Wong, Henry Li, Chuang-Chuang Asymmetric Total Syntheses of Colchicine, β‑Lumicolchicine, and Allocolchicinoid <i>N</i>‑Acetylcolchinol‑<i>O</i>‑methyl Ether (NCME) A concise and highly enantioselective synthesis of colchicine (>99% <i>ee</i>) in eight steps and 9.3% overall yield, without the need for protecting groups, was developed. A unique Wacker oxidation was used for enabling regioselective construction of the highly oxidized and synthetic challenging tropolone C-ring. Furthermore, asymmetric syntheses of β-lumicolchicine and <i>N</i>-acetylcolchinol-<i>O</i>-methyl ether (NCME) were achieved. Notably, NCME was synthesized from β-lumicolchicine by an unusual decarbonylation and electrocyclic ring-opening cascade reaction. β- lumicolchicine;NCME;methyl;electrocyclic ring-opening cascade reaction 2017-08-19
    https://acs.figshare.com/articles/dataset/Asymmetric_Total_Syntheses_of_Colchicine_Lumicolchicine_and_Allocolchicinoid_i_N_i_Acetylcolchinol_i_O_i_methyl_Ether_NCME_/5327455
10.1021/acs.orglett.7b02224.s002