10.6084/m9.figshare.5302942.v4
Lior Greenbaum
Lior
Greenbaum
Ramit Ravona-Springer
Ramit
Ravona-Springer
Abigail Livny
Abigail
Livny
Shahar Shelly
Shahar
Shelly
Inbal Sharvit-Ginon
Inbal
Sharvit-Ginon
Ithamar Ganmore
Ithamar
Ganmore
Anna Alkelai
Anna
Alkelai
Anthony Heymann
Anthony
Heymann
Michal Schnaider Beeri
Michal
Schnaider Beeri
The <i>CADM2</i> gene is associated with processing speed performance – evidence among elderly with type 2 diabetes
Taylor & Francis Group
2017
CADM2
Digit Symbol Substitution Test; processing speed
cognition
type 2 diabetes
2017-11-09 13:43:33
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/The_i_CADM2_i_gene_is_associated_with_processing_speed_performance_evidence_among_elderly_with_Type_2_Diabetes/5302942
<p><b>Objectives:</b> Recent large-scale meta-analysis of genome-wide association studies (GWAS) from multiple cohorts, demonstrated the association of the single nucleotide polymorphism (SNP) rs17518584, with processing speed (measured by the Digit Symbol Substitution Test (DSST) or the Letter Digit Substitution Test (LDST)), at GWAS significance level. This SNP is located within the cell adhesion molecule 2 (<i>CADM2</i>) gene. We aimed to validate this finding in our sample of 944 cognitively normal Jewish elderly individuals with type 2 diabetes (T2D), a population which is at risk for cognitive decline and dementia.</p> <p><b>Methods:</b> Using linear regression, we studied the association of rs17518584 with DSST performance, adjusting for demographic, T2D-related characteristics and cardiovascular factors. In secondary analyses, associations with performance in four cognitive domains (episodic memory, language/semantic categorisation, attention/working memory and executive function) and overall cognition were examined.</p> <p><b>Results:</b> Controlling for sex, age at cognitive assessment, years of education and ancestry, we found a significant association of rs17518584 with DSST performance (<i>P</i> = 0.013), consistent with the originally reported effect direction. Results remained significant even when the additional covariates (T2D-related and cardiovascular factors) were included in the analysis (<i>P</i> = 0.034). Moreover, this SNP was significantly associated with performance in the cognitive domains of language/semantic categorisation and executive function, as well as overall cognition.</p> <p><b>Conclusions:</b> Taken together, irrespective of T2D-related characteristics and cardiovascular factors, our findings provide independent support for the association of <i>CADM2</i> SNP rs17518584 with processing speed (and demonstrate association with additional cognitive phenotypes), among cognitively normal elderly individuals with T2D.</p>