Anticancer activity and Molecular mechanisms of a selected diarylpentanoid treated on androgen-independent metastatic human prostate cancer cells KAMINI CITALINGAM MUDLIAR 10.4225/03/598bb5e5f02f3 https://bridges.monash.edu/articles/thesis/Anticancer_activity_and_Molecular_mechanisms_of_a_selected_diarylpentanoid_treated_on_androgen-independent_metastatic_human_prostate_cancer_cells/5288263 Prostate cancer remains incurable, highlighting a need for alternative treatment methods using natural sources. Specific structural modification on curcumin, an active ingredient of the spice turmeric to produce curcumin diarylpentanoid demonstrated improved anticancer activity on prostate cancer cells; evident by its significant growth suppressive effect and cancer killing potential. Investigation on gene and protein expression study provided an understanding into the potential anticancer activity of the compound. Overall, curcumin diarylpentanoid demonstrated potential anticancer activity and warrants further research for its use in the treatment of prostate cancer. 2017-08-10 01:24:52 Androgen-independent prostate cancer diarylpentanoids Cytotoxicity Apoptosis Gene expression profiling Protein expression profiling pathway analysis Cancer Therapy (excl. Chemotherapy and Radiation Therapy)