%0 Journal Article %A Yan, Bin %A Chen, Zhihua %A Zhai, Xuguang %A Yin, Guibo %A Ai, Yafei %A Chen, Guangtong %D 2017 %T Microbial carbonylation and hydroxylation of 20(R)-panaxadiol by Aspergillus niger %U https://tandf.figshare.com/articles/journal_contribution/Microbial_carbonylation_and_hydroxylation_of_20_i_R_i_-panaxadiol_by_i_Aspergillus_niger_i_/5271526 %R 10.6084/m9.figshare.5271526.v1 %2 https://ndownloader.figshare.com/files/9019579 %K Biotransformation %K 20(R)-panaxatriol %K Aspergillus niger %K anti-hepatic fibrosis %X

20(R)-panaxadiol (PD) was metabolised by the fungus Aspergillus niger AS 3.3926 to its C-3 carbonylated metabolite and five other hydroxylated metabolites (1–6). Their structures were elucidated as 3-oxo-20(R)-panaxadiol (1), 3-oxo-7β-hydroxyl- 20(R)-panaxadiol (2), 3-oxo-7β,23α-dihydroxyl-20(R)-panaxadiol (3), 3,12-dioxo- 7β,23β-dihydroxyl-20(R)-panaxadiol (4), 3-oxo-1α,7β-dihydroxyl-20(R)-panaxadiol (5) and 3-oxo-7β,15β-dihydroxyl-20(R)-panaxadiol (6) by spectroscopic analysis. Among them, compounds 26 were new compounds. Pharmacological studies revealed that compound 6 exhibited significant anti-hepatic fibrosis activity.

%I Taylor & Francis