%0 Journal Article %A Bhalla, Jitender %A Bari, Shamsher S. %A Banik, Bimal K. %A Bhalla, Aman %D 2017 %T Diastereoselective synthesis of novel 3-aryloxy/alkoxy-4-benzothiazolylpyrazolyl-β-lactams: Potential synthons for novel aminoacids/nanocopolymers %U https://tandf.figshare.com/articles/journal_contribution/Diastereoselective_synthesis_of_novel_3-aryloxy_alkoxy-4-benzothiazolylpyrazolyl-_-lactams_Potential_synthons_for_novel_aminoacids_nanocopolymers/5255608 %R 10.6084/m9.figshare.5255608.v1 %2 https://ndownloader.figshare.com/files/8988100 %K Benzothiazole %K diastereoselective %K pyrazole %K trans-β-lactams %X

A fast, efficient, and diastereoselective synthesis of novel 3-oxo-4-benzothiazolylpyrazolyl-β-lactams is described. The reaction between 2-aryloxy/alkoxyacetic acid and novel benzothiazolylpyrazole-substituted imines afforded exclusive formation of trans-β-lactams. The scope of the reaction was investigated by varying different groups on substrates (R1, R2, R3, Z). All the novel compounds were characterized using various spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR, elemental analysis, and mass spectrometry in representative cases. No report has been listed in the literature for the synthesis of these types of β-lactam heterocycles so far.

%I Taylor & Francis