10.6084/m9.figshare.5255608.v1
Jitender Bhalla
Jitender
Bhalla
Shamsher S. Bari
Shamsher S.
Bari
Bimal K. Banik
Bimal K.
Banik
Aman Bhalla
Aman
Bhalla
Diastereoselective synthesis of novel 3-aryloxy/alkoxy-4-benzothiazolylpyrazolyl-β-lactams: Potential synthons for novel aminoacids/nanocopolymers
Taylor & Francis Group
2017
Benzothiazole
diastereoselective
pyrazole
trans-β-lactams
2017-07-28 14:12:36
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Diastereoselective_synthesis_of_novel_3-aryloxy_alkoxy-4-benzothiazolylpyrazolyl-_-lactams_Potential_synthons_for_novel_aminoacids_nanocopolymers/5255608
<p>A fast, efficient, and diastereoselective synthesis of novel 3-oxo-4-benzothiazolylpyrazolyl-β-lactams is described. The reaction between 2-aryloxy/alkoxyacetic acid and novel benzothiazolylpyrazole-substituted imines afforded exclusive formation of <i>trans</i>-β-lactams. The scope of the reaction was investigated by varying different groups on substrates (R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, Z). All the novel compounds were characterized using various spectroscopic techniques such as FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, elemental analysis, and mass spectrometry in representative cases. No report has been listed in the literature for the synthesis of these types of β-lactam heterocycles so far.</p>