%0 Journal Article %A T., Ohtsu %A A., Takagi %A N., Uemura %A K., Inoue %A H., Sekino %A A., Kawashima %A M., Uchida %A Y., Koga %D 2017 %T Supplementary Material for: The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study %U https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_The_Ameliorating_Effect_of_Lactobacillus_gasseri_OLL2716_on_Functional_Dyspepsia_in_Helicobacter_pylori-Uninfected_Individuals_A_Randomized_Controlled_Study/5255212 %R 10.6084/m9.figshare.5255212.v1 %2 https://ndownloader.figshare.com/files/8985940 %K Probiotics %K Epigastric %K Postprandial distress syndrome %K Functional gastrointestinal disorder %K Rome III classification %X

Background/Aims: Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected individuals with functional dyspepsia (FD). Methods: A double-blind, parallel-group, placebo-controlled, randomized, controlled trial was performed. Participants were randomly assigned to ingest L. gasseri OLL2716-containing yogurt (L. gasseri OLL2716 group) or L. gasseri OLL2716-free yogurt (placebo group) for 12 weeks. Participants completed questionnaires that dealt with a global assessment as well as symptom severity. The per-protocol (PP) population was evaluated for efficacy in accordance with a plan prepared beforehand. Results: Randomization was performed on 116 individuals; the PP population consisted of 106 individuals (mean age 42.8 ± 9.0). The impressions regarding the overall effect on gastric symptoms were more positive in the L. gasseri OLL2716 group compared to that in the placebo group (statistical trend; p = 0.073). The elimination rate for major FD symptoms was 17.3 and 35.3% in the placebo and L. gasseri OLL2716 groups respectively (p = 0.048). Conclusion:L. gasseri OLL2716 has beneficial effects on FD without H. pylori involvement.

%I Karger Publishers